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Cayman Probenecid-d14
List Price
$160.00
Your Price
$160.00
Cayman Probenecid-d14 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-26787-1
MFG.PART:
26787-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Probenecid-d14 is intended for use as an internal standard for the quantification of probenecid (Item No. ) by GC- or LC-MS. Probenecid is a benzoic acid derivative that inhibits organic anion transporters (OATs) but activates the transient receptor potential (TRP) channel TRPV2. It inhibits OAT1, OAT3, and OAT6 with Ki values of 6.3, 9.0, and 8.4 µM, respectively, as well as OAT2 with an IC50 value of 0.67 µM.,, It is a poor inhibitor of the organic cation transporters OCT1 and OCT2 (IC50 = 1.6 and 1.7 mm, respectively). It also acts as an agonist of TRPV2 (EC50 = 31.9 µM), eliciting nociceptive behavior under inflammatory conditions in mice. Formulations containing probenecid have been used in the treatment of gouty arthritis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[[di(propyl-
CAS Number
1189657-87-1
Molecular Formula
C13H5D14NO4S
Formula Weight
299.4
Purity
≥99% deuterated forms (d1-d14)
Formulation
A solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 10 mg/mL
SMILES
O=C(O)C1=CC=C(S(N(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])(=O)=O)C=C1
InChi Code
InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)/i1D3,2D3,3D2,4D2,9D2,10D2
InChi Key
DBABZHXKTCFAPX-YTSTUSJFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-26787-1 |
|---|---|
| Supplier Part Number | 26787-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1189657-87-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |