Cayman Roridin E

Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria. It inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC₅₀s = 0.4, 0.4, 1.4, and 1 μM, respectively). Roridin E induces cytotoxicity in multiple breast cancer cell lines (IC₅₀s = 0.02-0.05 nM) and inhibits proliferation in a panel of additional cancer cell lines (IC₅₀s = <0.01 μM).^, It also inhibits proliferation of the mammalian H4TG, MDCK, NIH3T3, and KA31T cell lines (IC₅₀s = 1.74-7.68 nM). Roridin E inhibits the growth of P. falciparum (EC₅₀ = 0.15 ng/mL), induces phytotoxicity in duckweed and kudzu, and is toxic to mice (LD₅₀ = 10 mg/kg, i.p.).^, Roridin E is also produced by the plant B. coridifolia, which is associated with livestock poisoning in South America.

WARNING This product is not for human or veterinary use.