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Cayman SR 3029
List Price
$178.00
Your Price
$178.00
Cayman SR 3029 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-27048-10
MFG.PART:
27048-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
SR 3029 is an inhibitor of casein kinase 1δ (CK1δ) and CK1ε (IC50s = 44 and 260 nM, respectively). It is selective for CK1δ and CK1ε over 438 kinases in a panel but also inhibits MYLK4, FLT3, Cdk4/cyclin D1, and MARK2 by greater than 90% at 10 µM. SR 3029 inhibits Cdk4/cyclin D1, Cdk4/cyclin D3, Cdk6/cyclin D1, Cdk6/cyclin D3, and FLT3 with IC50 values of 576, 368, 428, 427, and 3,000 nM, respectively. It inhibits proliferation of A375 human melanoma cells in vitro (EC50 = 86 nM). SR 3029 (20 mg/kg per day) reduces tumor growth and increases lifespan in MDA-MB-231 and MDA-MB-468 mouse xenograft models. It reduces the expression of the Wnt/β-catenin target CCND1 and decreases protein levels of nuclear β-catenin and cyclin D1 in mouse tumor tissue.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(6,7-
CAS Number
1454585-06-8
Molecular Formula
C23H19F3N8O
Formula Weight
480.5
Purity
≥98%
Formulation
A solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
λmax
231, 281 nm
SMILES
FC1=C(F)C(N2)=C(C=C1)N=C2CNC3=C4C(N(C5=CC=CC(F)=C5)C=N4)=NC(N6CCOCC6)=N3
InChi Code
InChI=1S/C23H19F3N8O/c24-13-2-1-3-14(10-13)34-12-28-20-21(31-23(32-22(20)34)33-6-8-35-9-7-33)27-11-17-29-16-5-4-15(25)18(26)19(16)30-17/h1-5,10,12H,6-9,11H2,(H,29,30)(H,27,31,32)
InChi Key
CEBMEQPREMCWOL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27048-10 |
|---|---|
| Supplier Part Number | 27048-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1454585-06-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |