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Cayman 3,4-Methylenedioxy-?-Ethylmethylaminohexanophenone (Hydroc
List Price
$81.00
Your Price
$81.00
Cayman 3,4-Methylenedioxy-?-Ethylmethylaminohexanophenone (Hydrochloride), 1-(Benzo[D][1,3]Dioxol-5-Yl)-2-(Ethyl(Methyl)Amino)Hexan-1-One, Monohydrochloride, 1 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-27077-1
MFG.PART:
27077-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Lacidipine is a dihydropyridine L-type calcium channel blocker. It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 µM. It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[2-[(1E)-3-
CAS Number
103890-78-4
Synonyms
- GX 1048
- GR 43659X
Molecular Formula
C26H33NO6
Formula Weight
455.5
Purity
≥98%
Formulation
A solid
Solubility
- DMF: 25mg/mL
- DMF:PBS (pH 7.2) (1:3): 0.25mg/mL
- DMSO: 20mg/mL
- Ethanol: 5mg/ml
λmax
240, 284, 368 nm
SMILES
CC1=C(C(OCC)=O)C(C2=C(/C=C/C(OC(C)(C)C)=O)C=CC=C2)C(C(OCC)=O)=C(C)N1
InChi Code
InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+
InChi Key
GKQPCPXONLDCMU-CCEZHUSRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27077-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 27077-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |