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Cayman Imidazole Ketone Erastin
List Price $105.00 Your Price $105.00
Cayman Imidazole Ketone Erastin - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-27088-1
MFG.PART: 27088-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Imidazole ketone erastin is an inducer of ferroptosis. It inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50 = 30 nM), indicating inhibition of the system xc- cystine/glutamate transporter. Imidazole ketone erastin increases production of lipid reactive oxygen species (ROS) in SUDHL6 diffuse large B cell lymphoma (DLBCL) cells in a concentration-dependent manner, as well as reduces glutathione (GSH) levels in these cells (IC50 = 34 nM). It inhibits the growth of HT-1080 fibrosarcoma cells (GI50 = 310 nM) as well as HRASG12V-overexpressing BJeLR cells (IC50 = 3 nM). Imidazole ketone erastin (23 and 40 mg/kg) reduces tumor growth in an SUDHL6 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[4-[2-(4-
CAS Number
1801530-11-9
Synonyms
- IKE
Molecular Formula
C35H35ClN6O5
Formula Weight
655.1
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10mg/mL
- DMSO: 1mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.25mg/mL
λmax
227, 275 nm
SMILES
O=C1N(C2=CC(C(CN3C=NC=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=CC=CC=C61
InChi Code
InChI=1S/C35H35ClN6O5/c1-24(2)47-32-12-7-25(31(43)20-40-14-13-37-23-40)19-30(32)42-33(38-29-6-4-3-5-28(29)35(42)45)21-39-15-17-41(18-16-39)34(44)22-46-27-10-8-26(36)9-11-27/h3-14,19,23-24H,15-18,20-22H2,1-2H3
InChi Key
PSPXJPWGVFNGQI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27088-1 |
|---|---|
| Supplier Part Number | 27088-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1801530-11-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |