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Cayman CGP 52432
List Price
$530.00
Your Price
$530.00
Cayman CGP 52432 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-27212-25
MFG.PART:
27212-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
CGP 52432 is an antagonist of GABAB receptors.1 It selectively reverses (–)-baclofen-induced inhibition of potassium-evoked GABA release over glutamate or somatostatin release (IC50s = 0.085, 3.35, and 9.26 μM, respectively) from rat cortical synaptosomes. CGP 52432 (10 μM) reduces paired-pulse inhibition of monosynaptic inhibitory potentials (IPSPs) by 80% in CA1 pyramidal neurons in rat hippocampal slices.2 It increases cell proliferation in the ventral subgranular zone of the dentate gyrus when administered at a dose of 3 mg/kg per day for 21 days and reduces immobility in the forced-swim test when administered at 10 mg/kg in stress-sensitive BALB/c mice.3 CGP 52432 (30 mg/kg) increases locomotor activity in mice.4 It also inhibits the analgesic effects of isovaline, GABA, and baclofen (Item No. 18600) in a mouse model of hindpaw allodynia induced by prostaglandin E2 (PGE2; Item No. 14010).5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
P-[3-[[(3,4-
CAS Number
139667-74-6
Molecular Formula
C15H24Cl2NO4P
Formula Weight
384.2
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
SMILES
ClC1=C(Cl)C=CC(CNCCCP(C(OCC)OCC)(O)=O)=C1
InChi Code
InChI=1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)
InChi Key
GJZVQXWEIYRHBE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27212-25 |
|---|---|
| Supplier Part Number | 27212-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 139667-74-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |