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Cayman (−)-MK-801 (maleate)
List Price $36.00 Your Price $36.00
Cayman (−)-MK-801 (maleate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-27213-5
MFG.PART: 27213-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
(–)-MK-801 is an NMDA receptor antagonist (Ki = 43 nM for inhibition of spermine binding) and an isomer of (+)-MK-801 (Item No. 10009019).1 In vivo, (–)-MK-801 blocks generalized seizures in a mouse model of epilepsy (ED50 = 0.85 mg/kg) and increases horizontal locomotor activity in mice (ED50 = 2.71 mg/kg).2 (–)-MK-801 (0.1 mg/kg) decreases immobility time in the tail suspension and forced swim tests in a mouse model of social defeat stress, indicating antidepressant-like activity.3 (–)-MK-801 also inhibits acetylcholinesterase (AChE) with Ki values of 6.2 and 7.9 μM for electric eel and rat brain AChE, respectively.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(5R,10S)-
CAS Number
121917-57-5
Molecular Formula
C16H15N • C4H4O4
Formula Weight
337.4
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 0.5 mg/mL
SMILES
[H][C@]12CC3=C(C=CC=C3)[C@](N2)(C)C4=CC=CC=C41.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m0./s1
InChi Key
QLTXKCWMEZIHBJ-FWHYOZOBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27213-5 |
|---|---|
| Supplier Part Number | 27213-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 121917-57-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |