Cayman GHRP-6 (acetate)

GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.^1,2,3,4 It inhibits binding of the GHS-R agonist MK-0677 (ibutamoren; Item No. 18003) to COS-7 cell membranes expressing human GHS-R type Ia (K_i = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (K_d = 260 nM).^2,3 GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC₅₀ = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC₅₀ = 0.83 nM).³ It also acts as a negative allosteric modulator of ghrelin (Item Nos. 15072 | 24458) signaling. GHRP-6 (0.03 μg/mL) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.¹ It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.⁴

WARNING This product is not for human or veterinary use.