Cayman GPR18 (C-Term) Polyclonal Antibody

GPR18 is a g protein-coupled receptor (GPCR) that is expressed in lymphoid tissues, lung, brain, testis, and ovaries. It is coupled to the g_αi/o and g_αq/11 transduction pathways and is activated by the polyunsaturated fatty acid metabolite resolvin D2 (Item No. ) and the endocannabinoid arachidonoyl glycine (NAGly; Item No. ). Resolvin D2-induced activation of GPR18 reduces inflammatory pain induced by formalin, carrageenan, and complete Freunds adjuvant (CFA) in rats and reduces production of pro-inflammatory cytokines in mouse models of cecal ligation and puncture-induced sepsis, ocular infections, and ischemic injury.^, NAGly-induced activation of GPR18 lowers intraocular pressure (IOP) in mice in a fatty acid amide hydrolase-dependent manner. GPR18 is also overexpressed and constitutively active in patient-derived metastatic melanoma tumor samples. Caymans GPR18 (C-Term) Polyclonal Antibody can be used for ELISA and immunohistochemistry (IHC) applications. The antibody recognizes the C-terminal region of GPR18 from human samples.

WARNING This product is not for human or veterinary use.