Cayman GPR99 (C-Term) Polyclonal Antibody

GPR99 is a g protein-coupled receptor (GPCR) that was originally identified as a purinergic receptor, P2Y15.^, However, it is activated by leukotriene E₄ (LTE₄; Item No. ) in the low nanomolar range and by α-ketoglutarate in the high micromolar range.^, It is found in the CNS, kidney, epididymis, and other tissues in the mouse, as well as in human kidney, nasal turbinates, and lung, among other tissues.^, GPR99 knockout in mice prevents vascular leakage induced by LTE₄ and epithelial cell mucin release in mouse nasal mucosa induced by LTE₄ or A. alternata. In the kidney, under acid-base stress, it is involved with the regulation of carbonic acid and sodium chloride resorption through activation by α-ketoglutarate. GPR99 is also expressed in mouse retina, and axon growth is increased when it is activated by α-ketoglutarate in isolated mouse embryo retinal explants. Cayman’s GPR99 (C-Term) Polyclonal Antibody can be used for Western blot and immunohistochemistry (IHC) applications. The antibody recognizes the C-terminus of GPR99 from human samples.

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