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Cayman PF-06409577
List Price $36.00 Your Price $36.00
Cayman PF-06409577 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-27366-1
MFG.PART: 27366-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PF-06409577 is an activator of AMP-activated protein kinase (AMPK) heterotrimers (Kd = 9 nM for α1β1γ1). In vitro, it selectively activates β1-containing AMPK isoforms (EC50s = 2.18-7.03 nM) over β2-containing isoforms (EC50s = ≥10 μM). PF-06409577 has an EC50 value of 7 nM in an activation/protection TR-FRET assay using α1β1γ1 AMPK. In vivo, PF-06409577 (≥10 mg/kg) increases phosphorylation of AMPK in rat kidney. It decreases urinary albumin levels in a ZSF1 obese rat model of diabetes, metabolic syndrome, and renal disease when administered at a dose of 100 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-chloro-5-
CAS Number
1467057-23-3
Molecular Formula
C19H16ClNO3
Formula Weight
341.8
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: soluble
λmax
245, 289 nm
SMILES
ClC(C=C(NC=C1C(O)=O)C1=C2)=C2C3=CC=C(C4(O)CCC4)C=C3
InChi Code
InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23)
InChi Key
FHQXLWCFSUSXBF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27366-1 |
|---|---|
| Supplier Part Number | 27366-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1467057-23-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |