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Cayman CAP 3
List Price
$69.00
Your Price
$69.00
Cayman CAP 3 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-27505-1
MFG.PART:
27505-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters. CAP 3 (40 mg/kg) also reduces bacterial load in E. coli-infected wounds in mice. It is cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells with a 50% lysis (HC50) value of 48 μM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-
CAS Number
2292123-03-4
Molecular Formula
C52H82N6O11
Formula Weight
967.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5mg/mL
- DMSO: 10mg/mL
- Ethanol: 10mg/mL
- PBS (pH 7.2): 3mg/mL
SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(OCC3=CC=CC=C3)=O)([H])[C@]4([H])[C@H](OC(CNC([C@@H](N)C(C)C)=O)=O)C[C@]5([H])C[C@H](OC(CNC([C@@H](N)C(C)C)=O)=O)CC[C@]5(C)[C@@]4([H])C[C@@H]1OC(CNC([C@@H](N)C(C)C)=O)=O
InChi Code
InChI=1S/C52H82N6O11/c1-28(2)45(53)48(63)56-24-41(60)67-34-19-20-51(8)33(21-34)22-38(68-42(61)25-57-49(64)46(54)29(3)4)44-36-17-16-35(31(7)15-18-40(59)66-27-32-13-11-10-12-14-32)52(36,9)39(23-37(44)51)69-43(62)26-58-50(65)47(55)30(5)6/h10-14,28-31,33-39,44-47H,15-27,53-55H2,1-9H3,(H,56,63)(H,57,64)(H,58,65)/t31-,33+,34-,35-,36+,37+,38-,39+,44+,45+,46+,47+,51+,52-/m1/s1
InChi Key
XOMVHDKAGAIFOU-ZJADFBSCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27505-1 |
|---|---|
| Supplier Part Number | 27505-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2292123-03-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |