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Cayman DMH4
List Price $218.00 Your Price $218.00
Cayman DMH4 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-27653-10
MFG.PART: 27653-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
DMH4 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.16 µM in a cell-free assay) and a derivative of dorsomorphin (Item No. 11967).1 It selectively inhibits VEGFR2 over activin receptor-like kinase 2 (ALK2), ALK5, and AMPK (IC50s = 3.5, >30, and 8 µM, respectively, in a cell-free assay). DMH4 inhibits growth of H460 and A549 human lung cancer cells (GI50s = 13.3 and 2.8 µM, respectively) and reduces VEGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs; IC50 = 1 µM).1,2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[4-[2-(4-
CAS Number
515880-75-8
Molecular Formula
C24H24N4O2
Formula Weight
400.5
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
λmax
290 nm
SMILES
C1(OCCN2CCOCC2)=CC=C(C(C=N3)=CN4C3=C(C5=CC=CC=C5)C=N4)C=C1
InChi Code
InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
InChi Key
SKZQZGSPYYHTQG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27653-10 |
|---|---|
| Supplier Part Number | 27653-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 515880-75-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |