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Cayman CZ415
List Price
$49.00
Your Price
$49.00
Cayman CZ415 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-27668-1
MFG.PART:
27668-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM). It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-[5,7-
CAS Number
1429639-50-8
Molecular Formula
C22H29N5O4S
Formula Weight
459.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:6): 0.1 mg/mL
- Ethanol: 10 mg/mL
λmax
303 nm
SMILES
C[C@H]1COCCN1C2=C3C(C(C)(C)S(C3)(=O)=O)=NC(C4=CC=C(NC(NCC)=O)C=C4)=N2
InChi Code
InChI=1S/C22H29N5O4S/c1-5-23-21(28)24-16-8-6-15(7-9-16)19-25-18-17(13-32(29,30)22(18,3)4)20(26-19)27-10-11-31-12-14(27)2/h6-9,14H,5,10-13H2,1-4H3,(H2,23,24,28)/t14-/m0/s1
InChi Key
IZLPVLBNRGPOHA-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27668-1 |
|---|---|
| Supplier Part Number | 27668-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1429639-50-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |