Cayman AKP-11

AKP-11 is an agonist of sphingosine-1-phosphate receptor 1 (S1P₁) with an EC₅₀ value of 0.047 μM for [³⁵S]GTPγS binding to CHO-K1 cell membranes expressing the human receptor. It decreases surface expression of S1P₁ and increases phosphorylation of Akt and ERK in CHO Cells expressing S1P₁-HA when used at a concentration of 100 nM. AKP-11 (1.3 and 3 mg/kg) reduces protein levels of IFN-γ and IL-17 in spinal cord tissue and decreases disease severity in a rat model of experimental autoimmune encephalomyelitis (EAE). It decreases peripheral counts of total lymphocytes and total, CD4⁺, CD8⁺, and CD26L⁺ T cells in an EAE rat model, as well as in healthy control animals, when administered at a dose of 1.3 mg/kg.

WARNING This product is not for human or veterinary use.