Cayman Phorbol 12,13-dibutyrate

Phorbol 12,13-dibutyrate is a phorbol ester and an activator of PKC, including group A (α and γ) and group B (δ, ε, η) PKC isoforms. It promotes tumor formation to a lesser degree than phorbol 12-myristate 13-acetate (TPA; Item No. ). Phorbol 12,13-dibutyrate induces papilloma formation in mice with a total dose of 9.7 µmol required to produce papillomas in 50% of survivors after eight weeks. It also induces inflammation in 50% of mice when administered topically to the ear at a dose of 0.067 µmol/ear.

WARNING This product is not for human or veterinary use.