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Cayman Bilobetin
List Price $54.00 Your Price $54.00
Cayman Bilobetin - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-27899-1
MFG.PART: 27899-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Bilobetin is a biflavonoid that has been found in g. biloba and has diverse biological activities.,, It is cytotoxic to HeLa, NCI-H460, Daudi, K562, SKOV3, MIA PaCa-2, and MCF-7 cells in vitro (IC50s = 14.79-97.28 μM). Bilobetin halts the cell cycle at the g2/M phase in HeLa cells in a concentration-dependent manner and induces apoptosis in HeLa cells when used at a concentration of 20 μM. It selectively inhibits matrix metalloproteinase-9 (MMP-9; IC50 = 10.33 μM) over MMP-2 and MMP-3 (IC50s = >100 μM). Bilobetin also inhibits aggregation of amyloid-β (1-40) peptide (Aβ40; Item No. ) in vitro with an IC50 value of 4.7 μM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
8-[5-(5,7-
CAS Number
521-32-4
Molecular Formula
C31H20O10
Formula Weight
552.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10mg/mL
- DMSO: 25mg/mL
- DMSO:PBS (pH 7.2) (1:6): 0.14mg/mL
- Ethanol: 2.5mg/mL
λmax
273, 335 nm
SMILES
OC1=CC(O)=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=C1C4=CC(C(OC5=C6C(O)=CC(O)=C5)=CC6=O)=CC=C4OC
InChi Code
InChI=1S/C31H20O10/c1-39-24-7-4-15(26-12-22(37)29-19(34)9-17(33)10-27(29)40-26)8-18(24)28-20(35)11-21(36)30-23(38)13-25(41-31(28)30)14-2-5-16(32)6-3-14/h2-13,32-36H,1H3
InChi Key
IWEIJEPIYMAGTH-UHFFFAOYSA-N
Origin
Plant/Ginkgo biloba L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-27899-1 |
|---|---|
| Supplier Part Number | 27899-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 521-32-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |