Cayman 1-Octacosanol

1-Octacosanol is a very long-chain fatty alcohol that has diverse biological activities, including antibacterial, antifungal, anti-inflammatory, and antioxidative properties.^,, It is active against the bacteria K. pneumoniae, S. flexneri, S. typhi, and E. faecalis (MICs = 4, 8, 2, and 32 µg/mL, respectively), as well as the pathogenic fungi T. ajelloi and T. rubrum (MICs = 4 and 32 µg/mL, respectively), but not the yeast C. albicans, C. lusitaniae, or C. krusei. It reduces the expression of TNF-α, inducible nitric oxide synthase (iNOS), IL-1β, and IL-6 in RAW 264.7 cells stimulated with LPS when used at concentrations of 30 and 100 µg/mL. 1-Octacosanol (100 mg/kg per day) increases body weight, decreases diarrhea and hematochezia, and improves histopathological and morphological changes in the colon in a mouse model of ulcerative colitis induced by dextran sulfate sodium (DSS; Item No. ). 1-Octacosanol (10, 50, or 100 mg/kg) reduces carbon tetrachloride-induced increases in serum transaminase, hepatic myeloperoxidase, and hepatic xanthine oxidase activity, as well as lipid peroxidation, in a rat model of acute liver injury progression. It also reverses decreases in hepatic superoxide dismutase and catalase activity, as well as glutathione (GSH) levels, in the same model.

WARNING This product is not for human or veterinary use.