Cayman α-Hederin

α-Hederin is a triterpenoid saponin that has been found in K. pictus and has diverse biological activities.^1,2,3,4 It increases spontaneous motoric activity in isolated rat stomach corpus and fundus strips when used at concentrations ranging from 25 to 320 μM.¹ It is cytotoxic to J82 and T24 human bladder carcinoma, Colon26 murine colon adenocarcinoma, and 3LL Lewis murine lung carcinoma cells (EC₅₀s = 15.5, 16.5, 12.5, and 1.1 μM, respectively).² α-Hederin (7.5 and 15 mg/kg) increases survival time in a 3LL Lewis mouse lung carcinoma model. It reduces acetic acid-induced writhing in mice when administered at doses of 10 and 20 mg/kg.³ α-Hederin (5, 10, and 20 mg/kg) reduces paw edema in a rat model of rheumatoid arthritis induced by Freunds complete adjuvant (FCA). It dose-dependently prevents carbon tetrachloride-induced increases in serum alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activity, as well as hepatic levels of malondialdehyde (MDA) in a mouse model of hepatic injury.⁴ α-Hederin also decreases levels of the cytochrome P450 (CYP) isoform CYP2E1 in mouse liver.

WARNING This product is not for human or veterinary use.