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Caymanvalerolactone; Purity- Greater Than Or Equal To 95%; Size
List Price
$70.00
Your Price
$70.00
Cayman -Valerolactone; Purity- Greater Than Or Equal To 95%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-28240-50
MFG.PART:
28240-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
NLRP3i is an intermediate in the synthesis of glyburide (Item No. ) and an inhibitor of the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome. It is selective for NLRP3 over NLRP4 and absent in melanoma 2 (AIM2) inflammasomes at 400 µM. NLRPi inhibits LPS-induced IL-1β release and apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization in J774A.1 mouse macrophages. In vivo, NLRP3i (100 mg/kg) reduces infarct size and cardiac levels of troponin I in a mouse model of acute myocardial infarction. It reduces peritoneal leukocyte infiltration in a mouse model of peritonitis induced by zymosan A (Item No. ) in a dose-dependent manner. NLRP3i (100 mg/kg) also decreases plasma IL-18 levels and reduces systolic and diastolic dysfunction in a mouse model of Western diet-induced obesity.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[2-[4-(amino
CAS Number
16673-34-0
Molecular Formula
C16H17ClN2O4S
Formula Weight
368.8
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:7): 0.14 mg/ml
λmax
227 nm
SMILES
ClC1=CC=C(OC)C(C(NCCC2=CC=C(S(N)(=O)=O)C=C2)=O)=C1
InChi Code
InChI=1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)
InChi Key
KVWWTCSJLGHLRM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28240-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 28240-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | Y |
| CAS Number | 108-29-2 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |