Cayman Aminooxyacetic Acid (hydrochloride)

Aminooxyacetic acid is a GABA transaminase (GABA-T) inhibitor (K_i = 9.16 μM) that induces GABA accumulation in the brain.¹ It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE; IC₅₀s = 8.5 and 1.1 μM, respectively).² Aminooxyacetic acid (100 mg/kg) decreases GABA-T activity, without affecting glutamic acid decarboxylase (GAD) activity, and increases GABA levels in all regions of rat brain.³ It also decreases GABA-T activity and increases GABA in mouse brain when administered at a dose of 13 mg/kg.⁴ Aminooxyacetic acid inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED₅₀s = 53, 130, and 85 mg/kg, respectively), however, it exhibits neurotoxicity in the chimney test (ED₅₀ = 62 mg/kg) and is lethal (LD₅₀ = 105 mg/kg) to mice.

WARNING This product is not for human or veterinary use.