Cayman Gemcitabine Elaidate

Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine (Item Nos. 11690 | 9003096) that contains an elaidic acid (Item No. 90250) moiety.¹ Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC₅₀s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells (IC₅₀s = 16 and 13 µM, respectively) or gemcitabine-resistant AG6000 cells (IC₅₀ = 91 µM). It inhibits growth of THX, LOX, MOLT-4, and MOLT-4/C8 cells in a manner independent of nucleoside transport. Gemcitabine elaidate reduces tumor growth in EKVX non-small cell lung cancer and MHMX sarcoma mouse xenograft models but not in an H-146 small cell lung cancer mouse xenograft model when administered at a dose of 40 mg/kg every three days.

WARNING This product is not for human or veterinary use.