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Cayman G150
List Price $121.00 Your Price $121.00
Cayman G150 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-28318-1
MFG.PART: 28318-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
G150 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50 = 10.2 nM for the human enzyme). It is selective for human cGAS over mouse cGAS (IC50 = 25,000 nM). G150 inhibits dsDNA-induced expression of IFNB1 in THP-1 cells and isolated human monocyte-derived macrophages (IC50s = 1.96 and 0.62 µM, respectively) but not LPS-induced expresssion of TNF or poly(I:C)-induced rRNA degradation in the same cells when used at a concentration of 10 µM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[9-(6-amino-
CAS Number
2369751-30-2
Molecular Formula
C18H16Cl2N4O2
Formula Weight
391.3
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMSO: soluble
λmax
234, 301 nm
SMILES
ClC1=CC(C2=CC=C(N)N=C2)=C3C(NC4=C3CN(C(CO)=O)CC4)=C1Cl
InChi Code
InChI=1S/C18H16Cl2N4O2/c19-12-5-10(9-1-2-14(21)22-6-9)16-11-7-24(15(26)8-25)4-3-13(11)23-18(16)17(12)20/h1-2,5-6,23,25H,3-4,7-8H2,(H2,21,22)
InChi Key
VVUOUIPXYFIWLE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28318-1 |
|---|---|
| Supplier Part Number | 28318-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2369751-30-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |