We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman SRT 2104
List Price $49.00 Your Price $49.00
Cayman SRT 2104 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-28380-1
MFG.PART: 28380-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SRT 2104 is an activator of sirtuin 1 (SIRT1). It increases renal SIRT1 activity and protein levels and decreases acetylation of the SIRT1 substrate p53 in a mouse model of diabetes induced by streptozotocin (STZ; Item No. ), as well as in non-diabetic control animals, when administered at a dose of approximately 100 mg/kg in the diet. SRT 2104 also decreases renal levels of inducible nitric oxide synthase (iNOS), reactive oxygen species (ROS), and malondialdehyde (MDA), as well as the fibrotic markers TGF-β1 and CTGF and the inflammatory markers PAI-1 and VCAM-1, in STZ-induced diabetic mice. SRT 2104 (0.5% in the diet) increases lifespan, improves motor function in the balance beam test, and reduces atrophy of the neocortex in the N171-82Q mouse model of Huntington’s disease.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-methyl-N-[2-
CAS Number
1093403-33-8
Molecular Formula
C26H24N6O2S2
Formula Weight
516.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 2 mg/mL
- DMSO: 2 mg/mL
- Ethanol: Partially soluble
- PBS (pH 7.2): Partially soluble
λmax
217, 298 nm
SMILES
O=C(C1=C(C)N=C(C2=CN=CC=C2)S1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCOCC6)=N4
InChi Code
InChI=1S/C26H24N6O2S2/c1-17-23(36-25(28-17)18-5-4-8-27-13-18)24(33)29-21-7-3-2-6-20(21)22-15-32-19(16-35-26(32)30-22)14-31-9-11-34-12-10-31/h2-8,13,15-16H,9-12,14H2,1H3,(H,29,33)
InChi Key
LAMQVIQMVKWXOC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28380-1 |
|---|---|
| Supplier Part Number | 28380-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1093403-33-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |