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Cayman PHA-680632
List Price
$185.00
Your Price
$185.00
Cayman PHA-680632 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-28381-25
MFG.PART:
28381-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
PHA-680632 is an inhibitor of Aurora A, B, and C kinases (IC50s = 27, 135, and 120 nM, respectively).1 It has greater than 15-fold selectivity for Aurora A kinase in a panel of 31 kinases. PHA-680632 inhibits phosphorylation of serine 10 on histone H3 in U2OS cells (IC50 = 0.39 µM). It inhibits proliferation of U2OS, HeLa, A549, HCT116, U937, and HL-60 cells (IC50s = 1.6, 0.4, 0.6, 0.1, 0.1, and 0.1 µM, respectively). PHA-680632 reduces the size of established tumors in transgenic v-Ha-ras mice and in an HL-60 human leukemia mouse xenograft model when administered at a dose of 45 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(2,6-
CAS Number
398493-79-3
Molecular Formula
C28H35N7O2
Formula Weight
501.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
λmax
310 nm
SMILES
O=C(NC1=C(CC)C=CC=C1CC)N(C2)CC3=C2NN=C3NC(C4=CC=C(N5CCN(C)CC5)C=C4)=O
InChi Code
InChI=1S/C28H35N7O2/c1-4-19-7-6-8-20(5-2)25(19)29-28(37)35-17-23-24(18-35)31-32-26(23)30-27(36)21-9-11-22(12-10-21)34-15-13-33(3)14-16-34/h6-12H,4-5,13-18H2,1-3H3,(H,29,37)(H2,30,31,32,36)
InChi Key
OBWNXGOQPLDDPS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-28381-25 |
|---|---|
| Supplier Part Number | 28381-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 398493-79-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |