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Cayman AMG 487
List Price $333.00 Your Price $333.00
Cayman AMG 487 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-28416-10
MFG.PART: 28416-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
AMG 487 is a chemokine (C-X-C motif) receptor 3 (CXCR3) antagonist (IC50 = 8.2 nM in a radioligand binding assay).1 It inhibits cell migration induced by chemokine (C-X-C motif) ligand 10 (CXCL10), CXCL11, and CXCL9 (IC50s = 8, 15, and 36 nM, respectively). In vivo, AMG 487 (3 mg/kg) inhibits bronchoalveolar lavage fluid (BALF) cell infiltration in a mouse model of bleomycin-induced cellular recruitment. It reduces the number of lung metastases in the K7M2 and Saos-LM7 osteosarcoma mouse xenograft models.2 AMG 487 (5 mg/kg) also restores mitochondrial function and inhibits mitochondrial-dependent hepatocellular apoptosis in a mouse model of non-alcoholic steatohepatitis (NASH).3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(1R)-1-[3-
CAS Number
473719-41-4
Molecular Formula
C32H28F3N5O4
Formula Weight
603.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: 60 mg/mL
λmax
269 nm
SMILES
O=C(N([C@@H](C1=NC(N=CC=C2)=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CN=CC=C4)CC5=CC=C(OC(F)(F)F)C=C5
InChi Code
InChI=1S/C32H28F3N5O4/c1-3-43-25-14-10-24(11-15-25)40-30(38-29-27(31(40)42)7-5-17-37-29)21(2)39(20-23-6-4-16-36-19-23)28(41)18-22-8-12-26(13-9-22)44-32(33,34)35/h4-17,19,21H,3,18,20H2,1-2H3/t21-/m1/s1
InChi Key
WQTKNBPCJKRYPA-OAQYLSRUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28416-10 |
|---|---|
| Supplier Part Number | 28416-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 473719-41-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |