Cayman Dihydrokainic Acid; Purity- Greater Than Or Equal To 95%;

Dihydrokainic acid (DHK) is an inhibitor of excitatory amino acid transporter 2 (EAAT2; K_i = 23 µM for glutamate uptake by COS cells expressing EAAT2).¹ It is selective for EAAT2 over EAAT1 and EAAT3 (K_i = >3 mM for both). DHK microinfusion (5 nmol) into the rat infralimbic cortex reduces the time spent immobile in the forced swim test, indicating antidepressant-like behavior, an effect that is blocked by the AMPA receptor antagonist NBQX (Item No. 14914) and the serotonin (5-HT) receptor subtype 5-HT_1A antagonist WAY-100635 (Item No. 14599).^2,3 It also increases glutamate and serotonin levels and the expression of c-Fos in the dorsal raphe nucleus. In contrast, DHK microinjection (6.25 nmol) into the rat prefrontal cortex (PFC) increases the latency to drink sucrose in a sucrose intake test, indicating anhedonia-like behavior.⁴ It also impairs memory acquisition, consolidation, and retrieval in mice in the novel object recognition test.⁵

WARNING This product is not for human or veterinary use.