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Cayman SR 27897
List Price
$231.00
Your Price
$231.00
Cayman SR 27897 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-28511-10
MFG.PART:
28511-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
SR 27897 is a nonpeptide cholecystokinin (CCK) receptor antagonist. It selectively binds to CCK1 receptors in rat pancreatic membranes (IC50 = 0.58 nM) over CCK2 receptors in guinea pig cortical membranes and gastrin receptors in guinea pig gastric gland suspensions (IC50s = 489 and 2,883 nM, respectively). SR 27897 inhibits amylase secretion induced by CCK in isolated rat pancreatic acini (PA2 = 7.50) and CCK-induced guinea pig gallbladder contractions ex vivo (PA2 = 9.57). It completely reverses CCK-induced amylase secretion in rats when administered at a dose of 1 mg/kg. SR 27897 also inhibits CCK-induced gastric and gallbladder emptying in mice (ED50s = 3 and 72 μg/kg, respectively). SR 27897 inhibits gallbladder emptying in a mouse model of egg yolk-stimulated endogenous CCK release (ED50 = 27 μg/kg).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[[4-(2-
CAS Number
136381-85-6
Synonyms
- Lintitript
Molecular Formula
C20H14ClN3O3S
Formula Weight
411.9
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: soluble
λmax
321 nm
SMILES
O=C(NC1=NC(C2=CC=CC=C2Cl)=CS1)C3=CC4=CC=CC=C4N3CC(O)=O
InChi Code
InChI=1S/C20H14ClN3O3S/c21-14-7-3-2-6-13(14)15-11-28-20(22-15)23-19(27)17-9-12-5-1-4-8-16(12)24(17)10-18(25)26/h1-9,11H,10H2,(H,25,26)(H,22,23,27)
InChi Key
ILNRQFBVVQUOLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28511-10 |
|---|---|
| Supplier Part Number | 28511-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 136381-85-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |