Cayman Ethacrynic Acid-d5

Ethacrynic acid-d₅ is intended for use as an internal standard for the quantification of ethacrynic acid (Item No. ) by GC- or LC-MS. Ethacrynic acid is a loop diuretic with anticancer activity.^,, It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC₅₀ = 0.18 mm) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a concentration of 0.3 mm.^, Ethacrynic acid also inhibits glutathione S-transferase P1-1 (GSTP1-1) and GSTA3-3 (IC₅₀s = 4.9 and ~0.4 μM, respectively), and inhibits Wnt/β-catenin signaling in a cell-based reporter assay.^, It is cytotoxic to primary chronic lymphocytic leukemia cells (IC₅₀ = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC₅₀s = 45.53, 39.64, and 25.23 μM, respectively).^, Ethacrynic acid (250 μg per day) increases tumor growth reduction induced by the EGFR family inhibitors afatinib (Item Nos. | ) or neratinib (Item No. ) in a 4T1 murine breast cancer model. Formulations containing ethacrynic acid have been used in the treatment of edema.

WARNING This product is not for human or veterinary use.