Cayman α-methyl Serotonin (maleate)

α-methyl Serotonin is an agonist of serotonin (5-HT) receptors.^, It binds selectively to 5-HT_1A, 5-HT_1B, 5-HT_1C, and 5-HT_1D receptors over 5-HT_1E receptors (K_is = 42, 85, 150, 150, and >10,000 nM, respectively). It is also selective for 5-HT_2B and 5-HT_2C receptors over 5-HT_2A receptors (EC₅₀s = 2.98, 50.1, and 794 nM, respectively). α-methyl Serotonin (30 μM) potentiates motor neuron depolarizations induced by NMDA (Item No. ) in the presence of the NMDA receptor antagonist memantine (Item No. ) in R. pipiens (frog) spinal cord ex vivo. It also increases dopamine release from rat striatum in vivo in a dose-dependent manner. α-methyl Serotonin (64 μg/kg) increases systolic blood pressure and transiently increases heart rate in conscious dogs.

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