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Cayman Demethylzeylasteral
List Price $128.00 Your Price $128.00
Cayman Demethylzeylasteral - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-28595-5
MFG.PART: 28595-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Demethylzeylasteral is a nortriterpenoid originally isolated from T. wilfordii that has diverse biological activities, including enzyme inhibitory, anti-angiogenic, antiproliferative, anti-inflammatory, and immunosuppressive properties.1,2,3,4 Demethylzeylasteral inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 (Kis = 0.6 and 17.3 μM, respectively).2 It inhibits growth of bovine aortic endothelial cells (BAEs) and U251 human glioma cancer cells in vitro (IC50s = 0.21 and ~6.2 μM, respectively), as well as inhibits tumor growth and neovascularization in vivo in a B16/F10 melanoma mouse allograft model when administered at a dose of 30 mg/kg per day.1 Demethylzeylasteral (0.12 mg/kg per day) decreases renal proteinuria, lesions, immune cell infiltration, and protein levels of TNF-α, COX-2, and ICAM-1 in lupus-prone MRL/lpr mice.3 Demethylzeylasteral (10 mg/kg per day) also increases survival of recipient rats in a model of kidney transplant.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(9β,13α,14β,
CAS Number
107316-88-1
Molecular Formula
C29H36O6
Formula Weight
480.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 10 mg/mL
λmax
214, 269, 308, 371 nm
SMILES
O=CC1=C(C(C=C2[C@@]3(C)CC[C@]4(C)[C@]2(C)CC[C@]5(C)[C@@]4([H])C[C@@](C(O)=O)(C)CC5)=O)C3=CC(O)=C1O
InChi Code
InChI=1S/C29H36O6/c1-25-6-7-26(2,24(34)35)14-21(25)29(5)11-9-27(3)17-12-19(32)23(33)16(15-30)22(17)18(31)13-20(27)28(29,4)10-8-25/h12-13,15,21,32-33H,6-11,14H2,1-5H3,(H,34,35)/t21-,25-,26-,27+,28-,29+/m1/s1
InChi Key
ZDZSFWLPCFRASW-CPISFEQASA-N
Origin
Plant/Tripterygium wilfordii Hook F
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28595-5 |
|---|---|
| Supplier Part Number | 28595-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 107316-88-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |