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Cayman Gefitinib-based PROTAC 3
List Price
$28.00
Your Price
$28.00
Cayman Gefitinib-based PROTAC 3 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-28597-1
MFG.PART:
28597-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Gefitinib-based PROTAC 3 is a proteolysis-targeting chimera (PROTAC) comprised of the EGF receptor (EGFR) inhibitor gefitinib (Item No. ) linked to the von Hippel-Lindau (VHL) E3 ubiquitin ligase ligand VHL ligand 1 (Item No. ). In cell-based assays, gefitinib-based PROTAC 3 induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion with half-maximal degradation (DC50) values of 22.3 and 11.7 nM, respectively, but does not induce degradation of wild-type EGFR at concentrations up to 10 μM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2S,4R)-1-((S)-
CAS Number
2230821-27-7
Synonyms
- Gefitinib-based Proteolysis-targeting Chimera 3
Molecular Formula
C47H57ClFN7O8S
Formula Weight
934.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/mL
- DMF:PBS (pH 7.2) (1:3): 0.25 mg/mL
- DMSO: 16 mg/mL
- Ethanol: 10 mg/mL
λmax
252, 332 nm
SMILES
ClC1=CC(NC2=NC=NC3=C2C=C(OCCCCCOCCOCCC(N[C@@H](C(C)(C)C)C(N4C[C@H](O)C[C@H]4C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)C(OC)=C3)=CC=C1F
InChi Code
InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57)26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64-40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9-14,21,23-24,27-28,33,38,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)/t33-,38+,43-/m1/s1
InChi Key
NICKHWYZMNLEPJ-TZSMONEZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28597-1 |
|---|---|
| Supplier Part Number | 28597-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2230821-27-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |