Cayman Sulfapyridine

Sulfapyridine is a sulfonamide antibiotic with antibacterial and anti-inflammatory activities.¹ It is also a metabolite of sulfasalazine (Item No. 15025) formed through bacterial conversion in the colon.² It is active against strains of Y. enterocolitica and Salmonella (MICs = 3.1-25 and 25-100 μg/mL, respectively), as well as S. aureus (MBC = 0.8 μM).^3,4 It is an inhibitor of recombinant P. carinii dihydropteroate synthetase (DHPS; IC₅₀ = 0.18 μM).⁵ Sulfapyridine scavenges peroxyl radicals in an oxygen radical absorbance capacity (ORAC) assay.² It inhibits histamine release induced by compound 48/80 (Item No. 22173) from isolated rat peritoneal mast cells in a dose-dependent manner.⁶ Sulfapyridine (1 μg/kg) also inhibits compound 48/80-induced systemic allergic reaction in rats. Formulations containing sulfapyridine have previously been used in the treatment of dermatological conditions and ulcerative colitis.

WARNING This product is not for human or veterinary use.