Cayman Aceclofenac

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) and a derivative of diclofenac (Item Nos. | ). Aceclofenac inhibits the production of prostaglandin E₂ (PGE₂; Item No. ) and thromboxane B₂ (TXB₂; Item No. ) by 25 and 30%, respectively, in cell-free assays when used at concentrations of 10 and 100 µM, respectively. It selectively inhibits COX-2 in isolated whole blood (IC₅₀s = 0.8 and >100 µM for COX-2 and COX-1, respectively) and inhibits the production of PGE₂ in patient-derived human rheumatoid synovial cells (IC₅₀s = 1.9-29.4 nM).^, Aceclofenac reduces IL-1β-induced increases in IL-6 production by 21 and 43% in cultured chondrocytes without and with osteoarthritic lesions, respectively, when used at a concentration of 30 μM. Aceclofenac inhibits carrageenan-induced paw edema (ED₅₀ = 3.6 mg/kg) and abscess formation (ED₃₀ = 1.1 mg/kg) in rats. It also inhibits an increase in joint diameter in a rat model of arthritis induced by complete Freund’s adjuvant (CFA).

WARNING This product is not for human or veterinary use.