Cayman Tolcapone-d4

Tolcapone-d₄ is intended for use as an internal standard for the quantification of tolcapone (Item No. ) by GC- or LC-MS. Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT; K_i = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine (Item No. ) and L-DOPA (Item No. ).^, Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity.^, By inhibiting COMT, tolcapone increases L-DOPA efficacy and reduces L-DOPA-induced motor complications in animal models of Parkinson’s disease.

WARNING This product is not for human or veterinary use.