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Cayman AMN082
List Price $141.00 Your Price $141.00
Cayman AMN082 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-28779-10
MFG.PART: 28779-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7). It inhibits cAMP accumulation induced by forskolin in CHO Cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α1-adrenergic receptor (α1-AR). It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM. AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinsons disease induced by 6-hydroxy dopamine (6-OHDA; Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N,N′-bis
CAS Number
97075-46-2
Molecular Formula
C28H28N2 • 2HCl
Formula Weight
465.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 100 mm
- Ethanol: 1 mm
- Water: 5 mm
SMILES
C(C1=CC=CC=C1)(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
InChi Code
InChI=1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
InChi Key
YRQCDCNQANSUPB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28779-10 |
|---|---|
| Supplier Part Number | 28779-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 97075-46-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |