We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman GSK8612
List Price $438.00 Your Price $438.00
Cayman GSK8612 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-28813-50
MFG.PART: 28813-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
GSK8612 is an inhibitor of TANK-binding kinase 1 (TBK1; IC50 = 158 nM).1 It is selective for TBK1 over a panel of 285 kinases. GSK8612 inhibits IFN-α release in isolated human peripheral blood mononuclear cells (PBMCs) stimulated with polyinosinic-polycytidylic acid (poly(I:C); IC50 = 794 nM). It also inhibits IFN-β secretion in THP-1 cells stimulated with dsDNA-containing baculovirus or cGAMP (IC50s = 1,258 and 501 nM, respectively). GSK8612 (5 mg/kg) reduces tumor volume and increases the number of tumor-infiltrating CD8+ T cells in immunocompetent, but not immunodeficient, mice in a model of carbon tetrachloride-induced hepatocellular carcinoma (HCC).2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[[[5-bromo-
CAS Number
2361659-62-1
Molecular Formula
C17H17BrF3N7O2S
Formula Weight
520.3
Purity
≥95%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 5 mg/mL
- PBS (pH 7.2): 0.3 mg/mL
λmax
228 nm
SMILES
NS(C1=CC=C(CNC2=C(Br)C=NC(NC3=CN(CC(F)(F)F)N=C3C)=N2)C=C1)(=O)=O
InChi Code
InChI=1S/C17H17BrF3N7O2S/c1-10-14(8-28(27-10)9-17(19,20)21)25-16-24-7-13(18)15(26-16)23-6-11-2-4-12(5-3-11)31(22,29)30/h2-5,7-8H,6,9H2,1H3,(H2,22,29,30)(H2,23,24,25,26)
InChi Key
FFPHMUIGESPOTK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28813-50 |
|---|---|
| Supplier Part Number | 28813-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2361659-62-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |