Cayman Indole-3-propionic Acid

Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities.^,, It scavenges ABTS (Item No. ) radicals in a cell-free assay when used at concentrations ranging from 50 to 150 µM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC₅₀ = 180 µM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) (Item No. ) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; Item No. ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.

WARNING This product is not for human or veterinary use.