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Cayman BV6
List Price
$49.00
Your Price
$49.00
Cayman BV6 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-28830-1
MFG.PART:
28830-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 μM. BV6 (4 μM) induces NF-κB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells. It enhances radiosensitization and increases apoptosis in HCC193 and H460 non-small cell lung cancer (NSCLC) cell lines. BV6 (1 μM) induces cell death in a panel of 40 primary, patient-derived B cell precursor acute lymphoblastic leukemia (BCP-ALL) samples in a TNF-dependent manner. In vivo, BV6 (10 mg/kg) increases survival and the time to relapse in a high-risk BCP-ALL patient-derived xenograft (PDX) mouse model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4,4-(1,6-
CAS Number
1001600-56-1
Molecular Formula
C70H96N10O8
Formula Weight
1205.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 60mg/mL
SMILES
O=C(N[C@@H](C(C1=CC=CC=C1)C2=CC=CC=C2)C(NCCCCCCNC([C@H](C(C3=CC=CC=C3)C4=CC=CC=C4)NC([C@@H]5CCCN5C([C@H](C6CCCCC6)NC([C@@H](NC)C)=O)=O)=O)=O)=O)[C@@H]7CCCN7C([C@H](C8CCCCC8)NC([C@@H](NC)C)=O)=O
InChi Code
InChI=1S/C70H96N10O8/c1-47(71-3)63(81)75-59(53-37-21-11-22-38-53)69(87)79-45-27-41-55(79)65(83)77-61(57(49-29-13-7-14-30-49)50-31-15-8-16-32-50)67(85)73-43-25-5-6-26-44-74-68(86)62(58(51-33-17-9-18-34-51)52-35-19-10-20-36-52)78-66(84)56-42-28-46-80(56)70(88)60(54-39-23-12-24-40-54)76-64(82)48(2)72-4/h7-10,13-20,29-36,47-48,53-62,71-72H,5-6,11-12,21-28,37-46H2,1-4H3,(H,73,85)(H,74,86)(H,75,81)(H,76,82)(H,77,83)(H,78,84)/t47-,48-,55-,56-,59-,60-,61-,62-/m0/s1
InChi Key
DPXJXGNXKOVBJV-YLOPQIBLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28830-1 |
|---|---|
| Supplier Part Number | 28830-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1001600-56-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |