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Cayman Morusin
List Price $178.00 Your Price $178.00
Cayman Morusin - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-28857-10
MFG.PART: 28857-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Morusin is a prenylated flavonoid that has been found in M. alba and has diverse biological activities, including enzyme inhibitory, anti-inflammatory, and antiproliferative properties.,,, It inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A7, and UGT1A8 (IC50s = 4.23, 0.98, and 3 μM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, CYP2C9, and CYP2E1 (IC50s = 2.13, 1.27, 3.18, and 9.28 μM, respectively). Morusin (4 μM) inhibits histamine and leukotriene C4 (LTC4) production induced by A23187 (Item No. ) and phorbol 12-myristate 13-acetate (PMA; Item No. ) in mouse MC/9 mast cells. It also inhibits the growth of MCF-7, MDA‑MB‑231, and MDA‑MB‑453 breast cancer cells (IC50s = 13.53, 10.84, and 11.99 μM, respectively). Morusin (12.5 mg/kg per day) decreases colonic tissue damage, TGF-β1 levels, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity in a rat model of TNBS-induced ulcerative colitis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(2,4-di
CAS Number
62596-29-6
Synonyms
- Mulberrochromene
- NSC 649220
Molecular Formula
C25H24O6
Formula Weight
420.5
Purity
≥98%
Formulation
A solid
Solubility
- DMF: 20mg/mL
- DMF:PBS (pH 7.2) (1:3): 0.25mg/mL
- DMSO: 10mg/mL
- Ethanol: 15mg/mL
λmax
271 nm
SMILES
OC1=CC=C(C(OC2=C3C(O)=CC4=C2C=CC(C)(C)O4)=C(C/C=C(C)/C)C3=O)C(O)=C1
InChi Code
InChI=1S/C25H24O6/c1-13(2)5-7-17-22(29)21-19(28)12-20-16(9-10-25(3,4)31-20)24(21)30-23(17)15-8-6-14(26)11-18(15)27/h5-6,8-12,26-28H,7H2,1-4H3
InChi Key
XFFOMNJIDRDDLQ-UHFFFAOYSA-N
Origin
Plant/Cortex mori
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28857-10 |
|---|---|
| Supplier Part Number | 28857-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 62596-29-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |