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Cayman Rubitecan
List Price $124.00 Your Price $124.00
Cayman Rubitecan - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-28956-25
MFG.PART: 28956-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Rubitecan is a DNA topoisomerase I inhibitor.1,2 It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.1 Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively).3 It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(4S)-ethyl-4-
CAS Number
91421-42-0
Synonyms
- 9-nitro-20(S)-Camptothecin
- RFS 2000
Molecular Formula
C20H15N3O6
Formula Weight
393.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/mL
- DMSO: 25 mg/mL
- Ethanol: Slightly soluble
λmax
221, 240, 318, 334, 377 nm
SMILES
O=C([C@]1(O)CC)OCC2=C1C=C(C(N=C(C=CC=C3[N+]([O-])=O)C3=C4)=C4C5)N5C2=O
InChi Code
InChI=1S/C20H15N3O6/c1-2-20(26)13-7-16-17-10(8-22(16)18(24)12(13)9-29-19(20)25)6-11-14(21-17)4-3-5-15(11)23(27)28/h3-7,26H,2,8-9H2,1H3/t20-/m0/s1
InChi Key
VHXNKPBCCMUMSW-FQEVSTJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-28956-25 |
|---|---|
| Supplier Part Number | 28956-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 91421-42-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |