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Cayman PCI-29732
List Price $36.00 Your Price $36.00
Cayman PCI-29732 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29036-1
MFG.PART: 29036-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PCI-29732 is a multi-kinase inhibitor. It inhibits the Tec family kinase BTK and the Src family kinases LCK and LYN (Kis = 8.2, 4.6, and 2.5 nM, respectively), as well as the activity of three receptor tyrosine kinases and seven non-receptor tyrosine kinases by greater than 90% in a panel of over 100 kinases at 10 µM. PCI-29732 inhibits calcium flux in Ramos B cells and phosphorylation of phospholipase Cɣ1 (PLCɣ1) with IC50 values of 0.53 and 0.33 µM, respectively. It is cytotoxic to S1-MI-80, H460/MX20, and KBv200 cancer cells overexpressing the ATP-binding cassette transporter (IC50s = 7.8, 6.3, and 6.02 µM, respectively). PCI-29732 (20 mg/kg), in combination with the DNA topoisomerase I inhibitor topotecan (Item No. ), reduces tumor growth in an H460/MX20 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-
CAS Number
330786-25-9
Molecular Formula
C22H21N5O
Formula Weight
371.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMF:PBS (pH 7.2) (1:2): 0.3 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 5 mg/mL
λmax
262, 289 nm
SMILES
NC1=C(C(C2=CC=C(OC3=CC=CC=C3)C=C2)=NN4C5CCCC5)C4=NC=N1
InChi Code
InChI=1S/C22H21N5O/c23-21-19-20(26-27(16-6-4-5-7-16)22(19)25-14-24-21)15-10-12-18(13-11-15)28-17-8-2-1-3-9-17/h1-3,8-14,16H,4-7H2,(H2,23,24,25)
InChi Key
GMJUPMONHWAZCP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29036-1 |
|---|---|
| Supplier Part Number | 29036-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 330786-25-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |