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Cayman Voruciclib
List Price $583.00 Your Price $583.00
Cayman Voruciclib - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29085-10
MFG.PART: 29085-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Voruciclib is a pan-inhibitor of cyclin-dependent kinases (CDKs; Kis = 0.626-9.1 nM).1 It is selective for CDKs over male germ cell associated kinase (MAK) and intestinal cell kinase (ICK; Kis = 259 and 481 nM, respectively), in a panel of 48 kinases. Voruciclib decreases myeloid cell leukemia-1 (Mcl-1) levels and increases cleaved poly(ADP-ribose) polymerase (PARP) levels in six diffuse large B-cell lymphoma (DLBCL) cell lines when used at concentrations ranging from 0.5 to 5 µM. It reduces tumor growth by 56.3% in a Ri-1 mouse xenograft model when administered at a dose of 200 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[2-chloro-
CAS Number
1000023-04-0
Molecular Formula
C22H19ClF3NO5
Formula Weight
469.8
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: soluble
λmax
269 nm
SMILES
O=C1C=C(C2=C(Cl)C=C(C(F)(F)F)C=C2)OC3=C1C(O)=CC(O)=C3[C@@]4([H])[C@H](CO)N(C)CC4
InChi Code
InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2,1H3/t12-,14+/m1/s1
InChi Key
MRPGRAKIAJJGMM-OCCSQVGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29085-10 |
|---|---|
| Supplier Part Number | 29085-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1000023-04-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |