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Cayman Polyphyllin I
List Price $202.00 Your Price $202.00
Cayman Polyphyllin I - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29179-10
MFG.PART: 29179-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity. It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 µM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells. Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3β,25R)-
CAS Number
50773-41-6
Synonyms
- (+)-Polyphyllin D
Molecular Formula
C44H70O16
Formula Weight
855.0
Purity
≥95%
Formulation
A solid
Solubility
- DMF: 25mg/mL
- DMF:PBS (pH 7.2) (1:2): 0.3mg/mL
- DMSO: 20mg/mL
SMILES
C[C@]12C(C[C@@H](O[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4)[C@@H](O)[C@H](O[C@@H]5O[C@@H](CO)[C@H](O)[C@H]5O)[C@@H](CO)O3)CC2)=CC[C@]6([H])[C@]1([H])CC[C@@]7(C)[C@@]6([H])C[C@@]8([H])[C@]7([H])[C@H](C)[C@]9(OC[C@H](C)CC9)O8
InChi Code
InChI=1S/C44H70O16/c1-19-8-13-44(53-18-19)20(2)30-27(60-44)15-26-24-7-6-22-14-23(9-11-42(22,4)25(24)10-12-43(26,30)5)55-41-38(59-39-35(51)33(49)31(47)21(3)54-39)36(52)37(29(17-46)57-41)58-40-34(50)32(48)28(16-45)56-40/h6,19-21,23-41,45-52H,7-18H2,1-5H3/t19-,20+,21+,23+,24-,25+,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36+,37-,38-,39+,40+,41-,42+,43+,44-/m1/s1
InChi Key
LRRDDWMXYOSKIC-IPKCVOQPSA-N
Origin
Plant/Rhizoma paridis
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-29179-10 |
|---|---|
| Supplier Part Number | 29179-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 50773-41-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |