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Cayman GNE-493
List Price $29.00 Your Price $29.00
Cayman GNE-493 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29224-1
MFG.PART: 29224-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
GNE-493 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC50s = 3.4, 12, 16, 16, and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, and mTOR, respectively). It inhibits proliferation of PC3 and MCF-7.1 cells with IC50 values of 330 and 180 nM, respectively. GNE-493 (10 mg/kg per day) reduces tumor volume in PC3 and MCF-7.1 mouse xenograft models, which are PTEN negative or PI3Kα activating mutation positive, respectively. It also decreases relative levels of phosphorylated Akt, PRAS40, and S6RP in tumor tissue in the MCF-7.1 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(2-amino-5-
CAS Number
1033735-94-2
Molecular Formula
C17H20N6O2S
Formula Weight
372.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 16 mg/mL
- Ethanol: 0.5 mg/mL
λmax
271 nm
SMILES
NC1=NC=C(C2=NC(N3CCOCC3)=C4C(C=C(C(C)(O)C)S4)=N2)C=N1
InChi Code
InChI=1S/C17H20N6O2S/c1-17(2,24)12-7-11-13(26-12)15(23-3-5-25-6-4-23)22-14(21-11)10-8-19-16(18)20-9-10/h7-9,24H,3-6H2,1-2H3,(H2,18,19,20)
InChi Key
LEXMMFPAPDGYGZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29224-1 |
|---|---|
| Supplier Part Number | 29224-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1033735-94-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |