Cayman GABAA Receptor α5 Subunit Polyclonal Antibody

GABA_A receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.^, They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α_1-6, β_1-4, γ_1-3, δ, ε, π, θ, and ρ_1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α₁β₂γ₂ subunit-containing GABA_A receptors, the major isoform found in the brain.^, The α subunit of GABA_A receptors interfaces with a β subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. Approximately 5% of all GABA_A receptors contain α₅ subunits and up to 25% of these receptors are expressed in the hippocampus, a region of the brain associated with learning and memory. Deletions in GABRA5, which encodes the α5 subunit isoform, have been found on chromosome 15 in patients with Angelman syndrome who typically develop autism spectrum disorder (ASD). Levels of α₅ subunit-containing GABA_A receptors are decreased in postmortem hippocampal samples from patients with advanced Alzheimer’s disease, Down syndrome, or fetal alcohol syndrome. Cayman’s GABA_A Receptor α₅ Subunit Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the GABA_A receptor α₅ subunit at approximately 55 kDa from mouse and rat samples.

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