Cayman Butyric Acid-d7

Butyric acid-d₇ is intended for use as an internal standard for the quantification of sodium butyrate (Item No. 13121) by GC- or LC-MS. Butyric acid is a short-chain fatty acid.¹ It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.^1,2 Butyric acid is an inhibitor of histone deacetylase (HDAC; IC₅₀ = 90 µM in a cell-free assay).³ It induces differentiation, cell cycle arrest at the g₀ phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mm.^2,4,5,6 Butyric acid decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mm.⁵ It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day.⁴ Butyric acid also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2^-/-, mouse model of TNBS-induced colitis.⁷

WARNING This product is not for human or veterinary use.