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Cayman MK-8245
List Price $479.00 Your Price $479.00
Cayman MK-8245 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29421-10
MFG.PART: 29421-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively).1 It is selective for SCD1 over Δ5- and Δ6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC50 = 39.8 nM).2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[3-[4-(2-
CAS Number
1030612-90-8
Molecular Formula
C17H16BrFN6O4
Formula Weight
467.3
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
λmax
229 nm
SMILES
BrC1=CC=C(F)C=C1OC2CCN(C3=NOC(C4=NN(CC(O)=O)N=N4)=C3)CC2
InChi Code
InChI=1S/C17H16BrFN6O4/C18-12-2-1-10(19)7-13(12)28-11-3-5-24(6-4-11)15-8-14(29-22-15)17-20-23-25(21-17)9-16(26)27/h1-2,7-8,11H,3-6,9H2,(H,26,27)
InChi Key
UJEAABFSXKCSGI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29421-10 |
|---|---|
| Supplier Part Number | 29421-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1030612-90-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |