Cayman SB 222200

SB 222200 is a neurokinin-3 (NK₃) receptor antagonist (IC₅₀ = 18.4 nM). It is selective for NK₃ over NK₁ and NK₂ receptors (IC₅₀s = 250 and >100,000 nM, respectively). SB 222200 decreases calcium mobilization induced by neurokinin B (Item No. ) with an IC₅₀ value of 265 nM in HEK293 cells expressing the recombinant human receptor. It inhibits contractions induced by senktide (Item No. ) in isolated rabbit iris sphincter muscle when used at a concentration of 300 nM. SB 222200 (500 pmol, i.c.v.) decreases mean arterial pressure in spontaneously hypertensive, but not normotensive, rats. It prevents senktide-induced head shakes and tail whips in mice (ED₅₀ = 5.6 mg/kg).

WARNING This product is not for human or veterinary use.