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Cayman SM-324405
List Price $534.00 Your Price $534.00
Cayman SM-324405 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-29457-25
MFG.PART: 29457-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SM-324405 is a toll-like receptor 7 (TLR7) agonist (EC50 = 50.1 nM in a reporter assay using HEK293 cells expressing the human receptor).1 It is selective for TLR7 over TLR8 (EC50 = >10 µM). SM-324405 induces IFN production in isolated human peripheral blood mononuclear cells (PBMCs) with a minimum effective concentration (MEC) of 10 nM. It induces proliferation of isolated mouse, rat, and dog splenocytes (EC50s = 3.98, 6.31, and 12.59 nM, respectively).2 SM-324405 (0.1 and 1 mg/kg, intratracheally) inhibits bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a rat model of ovalbumin-sensitized and -challenged allergic airway inflammation.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[(6-amino-2-
CAS Number
677773-91-0
Molecular Formula
C19H23N5O4
Formula Weight
385.4
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: 100 mm
λmax
282 nm
SMILES
NC1=C2C(N(CC3=CC(CC(OC)=O)=CC=C3)C(N2)=O)=NC(OCCCC)=N1
InChi Code
InChI=1S/C19H23N5O4/c1-3-4-8-28-18-22-16(20)15-17(23-18)24(19(26)21-15)11-13-7-5-6-12(9-13)10-14(25)27-2/h5-7,9H,3-4,8,10-11H2,1-2H3,(H,21,26)(H2,20,22,23)
InChi Key
MXILFZWMVNDOIZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29457-25 |
|---|---|
| Supplier Part Number | 29457-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 677773-91-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |